Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines.

ABSTRACT: We have developed an enantiospecific, nickel-catalyzed cross-coupling of unsymmetric 1,3-disubstituted allylic pivalates with arylboroxines. The success of this reaction relies on the use of BnPPh2 as a supporting ligand for the nickel(0) catalyst and NaOMe as a base. This method shows excellent functional group tolerance and broad scope in both the allylic pivalate and arylboroxine, enabling the preparation of 1,3-diaryl allylic products in high yields with excellent levels of regioselectivity and stereochemical fidelity.

SUBMITTER: Srinivas HD 

PROVIDER: S-EPMC4084837 | biostudies-other | 2014 Jul

REPOSITORIES: biostudies-other