Ontology highlight
ABSTRACT:
SUBMITTER: Laughlin S
PROVIDER: S-EPMC4339222 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Laughlin Sarah S Wang Siming S Kumar Arvind A Boykin David W DW Wilson W David WD
Analytical and bioanalytical chemistry 20140730 25
Minor groove binding compounds have been shown to induce changes in global DNA conformation, allosterically inhibiting DNA-protein interactions necessary for transcriptional processes. Many minor groove binders are specific for AT base pairs but have little preference over alternating AT or A-tract sequences. Few compounds, other than polyamides, show selectivity for mixed sequences with AT and GC base pairs. Electrospray ionization mass spectrometry (ESI-MS) can provide insight on the stoichiom ...[more]