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Strengthening the Spleen and Reducing Phlegm Method in Improving Radical Resection Rate of Colorectal Cancer

ABSTRACT: This study will take disease-free survival time and recurrence and metastasis rate as the main evaluation indexes, to evaluate the clinical efficacy of strengthening the spleen and reducing phlegm method in patients with stage II high-risk and stage III colorectal cancer

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2287591 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Clinical study on strengthening spleen and relieving toxin decoction combination with first-line chemotherapy maintenance treatment for mCRC

Project description:Interventions: Treatment group and control group: strengthening spleen and relieving toxin decoction combination with first-line chemotherapy Primary outcome(s): PFS;Disease remission rate Study Design: Cross-sectional

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Effect of Supplementing Qi and strengthening spleen on the expression of TTR in serum of patients with colorectal carcinoma and its correlation with the dynamic changes of syndrome

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Improving rice population productivity by reducing nitrogen rate and increasing plant density.

Project description:In terms of tillering potential, the aboveground portions of rice are significantly influenced by the nitrogen level (NL) and transplant density (TD). To obtain a suitable combination of NL and TD, five NLs (0, 90, 180, 270 and 360 kg ha-1) and two TDs [high density (HD), 32.5×104 hills ha-1; low density (LD), 25.5×104 hills ha-1] were used in the rice experiments during 2012 to 2014, in Jiangsu, China. The results showed the highest grain yield of rice obtained at HD and LD when N supply was 180 and 270 kg ha-1, respectively. That's because there are more tillers per unit area, a larger leaf biomass fraction of total aboveground biomass, a larger leaf area index (LAI) and a larger canopy photosynthesis potential (CPP) at HD. It can be concluded that, higher rice planting densities resulted in less N inputs, while more N is needed to improve single plant actual tiller ability under low density to offset the reduced planting density. When the NL was more than 180 kg ha-1, the actual tillering ability of a single plant at LD was 20% more than that at HD. Based on these results, the supply of 1 kg N can be replaced by adding approximately 1000 planting hills per hectare. Therefore, adjusting the transplant density could be an efficient method to reduce the amount of nitrogen fertilizer and increase the nitrogen fertilizer use efficiency, which is very conducive to the sustainable development of agriculture.

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Project description:Spleen and Liver

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Isolation of spleen lymph during leukemia development

Project description:Here we asked whether infiltration of leukemic blasts initiated a response that could be detected in the interstitial fluid phase of the spleen in a rat model known to mimic human acute myeloid leukemia (AML). By cannulating efferent lymphatic vessels, we were able to monitor the response of the spleen microenvironment during leukemia development. Flow cytometric analysis of lymphocytes isolated from spleen lymph showed increased STAT3 and CREB signaling, and proteins related to these pathways were identified with a different profile in leukemic when compared with control spleen lymph. Additionally, SPARC-like 1 protein, recently identified as a promoter of AML cell growth and a biomarker of patient outcome, was locally produced in the spleen and upregulated in the leukemic setting. Thus, interstitial fluid, and its surrogate efferent lymph, can be used to provide unique information about spleen responses and substances released to the general circulation during leukemia development.

2023-06-23 | PXD011399 | Pride

Rat spleen proteomics profiling

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Decellularized splenic matrix as a scaffold for spleen bioengineering

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2018-02-07 | PXD005293 | Pride

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Project description:TCM-stimulated mouse spleen

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