Thivierge_etal_Drosha_BioID_2024

ABSTRACT: This dataset consists of the files for 22 BioID samples: .wiff and .wiff.scan raw MS files, .mzML peak files, and MSPLIT results files; all acquired on TripleTOF 6600 mass spectrometers operated in Data Independent Acquisition mode (SWATH). It also includes the sequence database used for analysis and the MSPLIT spectral library which was generated from paired samples acquired in Data Dependent Acquisition (DDA) mode. All streptavidin affinity purification, mass spectrometric acquisition, and data analysis was performed by Boris Dyakov. Samples were provided by Thomas Duchaine's lab (McGill University). The files are associated with a manuscript in Cell Reports by Thivierge et al. that explores the paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ, wherein SFPQ is identified as a proximally-associated protein for DROSHA. Only the Wildtype DROSHA bait data is used in the publication, but all files used in statistical analysis are provided. Thomas Duchaine is the corresponding author of the manuscript ([e-mail]) Anne-Claude Gingras should be contacted for questions about this dataset ([e-mail])

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000094396 | MassIVE | Mon Mar 25 04:28:00 GMT 2024

SECONDARY ACCESSION(S): PXD050949

REPOSITORIES: MassIVE