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Evaluation of the p53 isoform Δ133p53β aggregation capacity

ABSTRACT: p53 isoforms and particularly Δ133p53β play a critical role in cancer progression. We demonstrate that WT Δ133p53β activity is regulated through an aggregation-dependent mechanism. Creation of WT Δ133p53β aggregates depends on associations with specific interacting partners and was observed both in cancer cell lines and in human tumour biopsies.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Functional Proteomics Platform FPP

LAB HEAD: Pierre Roux

PROVIDER: PXD022998 | Pride | 2021-06-04

REPOSITORIES: Pride

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