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Bacteria initiates inflammaging leading to degenerative disc disease- evidence from host defense mechanism

ABSTRACT: Inflammaging is an established cause of degenerative disc disease (DDD), the possible triggers being genetic, mechanical, or infective. With rising evidence of subclinical infection and dysbiosis as initiators of degeneration, this study was undertaken to investigate the sequential molecular events associated with bacteria-induced changes in the host leadingto Inflammaging and DDD. Our study has documented increasing evidence for bacteria's role in triggering the innate immune system leading to chronic inflammation and degeneration.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Chondrocyte, Nucleus Pulposus, Lumbar Spine, Fibroblast

DISEASE(S): Degenerative Disc Disease

SUBMITTER: Chitraa Tangavel

LAB HEAD: Dr Chitraa Tangavel

PROVIDER: PXD023359 | Pride | 2025-01-07

REPOSITORIES: Pride

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			Action	DRS
	DD10_NP_S1_Pool1_1.mgf	Mgf
	DD10_NP_S1_Pool1_1.mzML	Mzml
	DD10_NP_S1_Pool1_1.mzid.gz	Mzid
	DD10_NP_S1_Pool1_1.raw	Raw
	DD10_NP_S1_Pool1_2.mgf	Mgf

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