Proteomics

Dataset Information

0

Peptidome of Bothrops cotiara snake venom

ABSTRACT: The knowledge regarding toxins diversity, composition, structure, molecular and pharmacological interactions involved in the process of envenomation provide lessons for drug design based on these natural molecular scaffolds and pharmacophores of toxins. This study unravels new toxins sequenced by mass spectrometry analysis of Bothrops cotiara peptidome, and the potential biological activities of these toxins were explored.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Bothrops Cotiara

TISSUE(S): Venom

SUBMITTER: Alexandre Keiji Tashima  

LAB HEAD: Alexandre Keiji Tashima

PROVIDER: PXD036130 | Pride | 2023-10-20

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
2022_Bcotiarapep.mgf Mgf
CompiledDB_BjGenome_BPPs_311entries.fasta Fasta
OB_BCOT_PEP_R1_20150409_16.raw Raw
OB_BCOT_PEP_R2_20150409_17.raw Raw
OB_BCOT_PEP_R3_20150409_18.raw Raw
Items per page:
1 - 5 of 9
altmetric image

Publications

Snake venoms are primarily composed of proteins and peptides, which selectively interact with specific molecular targets, disrupting prey homeostasis. Identifying toxins and the mechanisms involved in envenoming can lead to the discovery of new drugs based on natural peptide scaffolds. In this study, we used mass spectrometry-based peptidomics to sequence 197 peptides in the venom of Bothrops cotiara, including a novel 7-residue peptide derived from a snake venom metalloproteinase. This peptide,  ...[more]

Similar Datasets

Proteomics A novel peptide from Bothrops cotiara peptidome
2023-10-20 | PXD041473 | Pride
Proteomics Taxon-specific toxicity and composition of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)
2023-02-08 | PXD033502 | Pride
Proteomics Asp caterpillar (Megalopyge ssp.) venom proteomes
2024-01-26 | PXD037610 | Pride
Proteomics Qualitative and quantitative analysis of Bothrops jararaca venom gland proteome
2016-09-28 | PXD004186 | Pride
Proteomics Peptidomics of Acanthoscurria gomesiana spider venom reveals new toxins with potential antimicrobial activity
2016-08-02 | PXD003884 | Pride
Proteomics A multi-omics approach unravels new toxins with potential antimicrobial, antiviral and antitumoral activities in the venom of Acanthoscurria rondoniae
2020-07-20 | PXD019343 | Pride
Proteomics Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants
2024-06-16 | PXD043773 | Pride
Proteomics Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in giant centipedes
2024-08-29 | PXD048264 | Pride
Proteomics Physiological constraints dictate toxin spatial heterogeneity in snake venom glands
2022-06-10 | PXD034174 | Pride
Proteomics Exploring Top-Down Mass Spectrometric Approaches To Probe Forest Cobra (Naja melanoleuca) Venom Proteoforms
2024-09-05 | PXD052561 | Pride