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ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstrat...
ORGANISM(S): Homo Sapiens (human) 
2021-12-06 | PXD017922 | Pride
Post-translational modification Spliced peptides Immunopeptidome Hla Mass spectrometry Proteasome 
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ProteomicsNaturally processed flucloxacillin haptenated HLA ligands
This study has demonstrated that natural flucloxacillin haptenated HLA-B*57:01 ligands arepresented by antigen presenting cells through multiple pathways. Identification of such epitopes will help to define the chemical signals responsible for drug-induced immunological disease.
ORGANISM(S): Homo Sapiens (human) 
2020-08-05 | PXD020137 | Pride
Dili Hla-b*57:01 Flucloxacillin Drug hypersensitivity 
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ProteomicsC1R.B*58:01 MHC class I immunopeptidome LC-MSMS
Characterisation of peptide ligands of Major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I allele HLA-B*58:01.
ORGANISM(S): Homo Sapiens (human) 
2018-10-24 | PXD008572 | Pride
Hla-b*58:01 Lc-msms Immunopeptidome Mhc 
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ProteomicsC1R.B*57:01 MHC class I immunopeptidome LC-MSMS
Characterisation of peptide ligands of Major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I allele HLA-B*57:01.
ORGANISM(S): Homo Sapiens (human) 
2018-10-24 | PXD008570 | Pride
Hla-b*57:01 Lc-msms Immunopeptidome Mhc 
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ProteomicsImpacts of HLA-B57 micropolymorphism (MRM)
Comparison of peptide ligands of major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I alleles HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01.
ORGANISM(S): Homo Sapiens (human) 
2018-10-24 | PXD009850 | Pride
Immunopeptidome Mhc Mrm Hla-b57 
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ProteomicsC1R.B*57:03 MHC class I immunopeptidome LC-MSMS
Characterisation of peptide ligands of Major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I allele HLA-B*57:03.
ORGANISM(S): Homo Sapiens (human) 
2018-10-24 | PXD008571 | Pride
Hla-b*57:03 Lc-msms Immunopeptidome Mhc 
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ProteomicsNanobodies peptide/glycopeptide identification
Confirmation of Nanobody sequences and identification of Nanobody glycopeptide glycoforms.
ORGANISM(S): Lama Glama 
2021-09-09 | PXD023483 | Pride
Glycopeptides Nanobodies Ms-ms 
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UnknownThe relationship between sleep quality and neurocognition in bipolar disorder.
Not available
S-EPMC4598049 | biostudies-literature
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Metabolomics,MultiomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
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UnknownOptical single-shot readout of spin qubits in silicon.
Not available
S-EPMC11695859 | biostudies-literature
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