Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of human prostate cancer

ABSTRACT: miRNA expression profiling of 13 clinical prostate samples, 4 benign prostate hyperplasias, 5 untreated primary prostate carcinomas and 4 castration-resistant prostate cancers.

ORGANISM(S): Homo sapiens

DISEASE(S): untreated prostate cancer

SUBMITTER: Hanna Rauhala 

PROVIDER: E-MEXP-2319 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer.

Rauhala Hanna E HE   Jalava Sanni E SE   Isotalo Jarkko J   Bracken Hazel H   Lehmusvaara Saara S   Tammela Teuvo L J TL   Oja Hannu H   Visakorpi Tapio T  

International journal of cancer 20100901 6

miRNAs have proven to be key regulators of gene expression and are differentially expressed in various diseases, including cancer. Our aim was to identify epigenetically dysregulated genes in prostate cancer. We performed miRNA expression profiling after relieving epigenetic modifications in 6 prostate cancer cell lines and nonmalignant prostate epithelial cells. Thirty-eight miRNAs showed increased expression in any prostate cancer cell line after 5-aza-2'-deoxycytidine (5azadC) and trichostati  ...[more]

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