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Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus.

ABSTRACT: [structures: see text] Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

SUBMITTER: Kubanek J

PROVIDER: S-EPMC3374863 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature

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Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus.

Kubanek Julia J Prusak Anne C AC Snell Terry W TW Giese Rachel A RA Hardcastle Kenneth I KI Fairchild Craig R CR Aalbersberg William W Raventos-Suarez Carmen C Hay Mark E ME

Organic letters 20051101 23

[structures: see text] Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and ...[more]

PMID: 16268553

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