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Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.

ABSTRACT: Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).

SUBMITTER: Stout EP

PROVIDER: S-EPMC2646105 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.

Stout E Paige EP Hasemeyer Adam P AP Lane Amy L AL Davenport Theresa M TM Engel Sebastian S Hay Mark E ME Fairchild Craig R CR Prudhomme Jacques J Le Roch Karine K Aalbersberg William W Kubanek Julia J

Organic letters 20090101 1

Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus ...[more]

PMID: 19053716

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