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A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes.

ABSTRACT: 1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non-aqueous work-up in the final reductive step.

SUBMITTER: Doyle LR

PROVIDER: S-EPMC4498470 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes.

Doyle Laurence R LR Heath Alex A Low Choon Heng CH Ashley Andrew E AE

Advanced synthesis & catalysis 20140202 2-3

1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, <i>via</i> a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non-aqueous work-up in the final reductive step. ...[more]

PMID: 26190960

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