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Cembranolides and Related Constituents from the Soft Coral Sarcophyton cinereum.

ABSTRACT: In an attempt to explore the bioactive metabolites of the soft coral Sarcophyton cinereum, three new cembranolides, cinerenolides A-C (1-3), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new cembranolides were elucidated on the basis of spectroscopic analysis, and the NOE analysis of cinerenolide A (1) was performed with the assistance of the calculated lowest-energy molecular model. The relative configuration of cinerenolide C (3) was determined by the quantum chemical NMR calculation, followed by applying DP4+ analysis. In addition, the cytotoxic assays disclosed that some compounds exhibited moderate to potent activities in the proliferation of P388, DLD-1, HuCCT-1, and CCD966SK cell lines.

SUBMITTER: Chao CH

PROVIDER: S-EPMC8956058 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Cembranolides and Related Constituents from the Soft Coral Sarcophyton cinereum.

Chao Chih-Hua CH Chen Yi-Ju YJ Huang Chiung-Yao CY Chang Fang-Rong FR Dai Chang-Feng CF Sheu Jyh-Horng JH

Molecules (Basel, Switzerland) 20220308 6

In an attempt to explore the bioactive metabolites of the soft coral Sarcophyton cinereum, three new cembranolides, cinerenolides A-C (1-3), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new cembranolides were elucidated on the basis of spectroscopic analysis, and the NOE analysis of cinerenolide A (1) was performed with the assistance of the calculated lowest-energy molecular model. The relative configuration of cin ...[more]

PMID: 35335127

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